The new standard in antioxidant protection. A blend of 5 potent and proven antioxidants, including punicalagin from pomegranate, in one easy-to-take capsule. A synergistic blend of 5 antioxidants, including punicalagin. Found only in the skin of the pomegranate, the punicalagin molecule is responsible for this fruit's antioxidant potency (up to 10 times stronger than ellagic acid) (1,2). Pomegranate Plus contains a patent-pending, full-spectrum, watersoluble pomegranate extract standardized to punicalagin and made from whole, hand-picked, non-GMO pomegranates grown without pesticides or chemical fertilizers.

Because antioxidants are more effective when taken together, working synergistically to eliminate free radicals, we've blended 5 supreme antioxidants to create Pomegranate Plus: full-spectrum, watersoluble extracts from pomegranate, green tea, grape seed and bilberry, as well as vitamin C. Pomegranate Plus is a potent and comprehensive defense against free radicals. Studies conducted on individual ingredients indicate they may help to improve circulation (3,4), lower cholesterol (5), strengthen immunity (6) and slow the aging process (7).

The power of punicalagin
Scientific findings:Research has determined that the antioxidant power of the pomegranate comes predominantly from the polyphenol punicalagin (1,2). While many pomegranate products boast of high ellagic acid content, ellagic acid is highly insoluble in water and poorly absorbed in free form (8,9,10). As well, antioxidants extracted and isolated from their natural source may actually increase free radical occurrence in the body. Ellagic acid is most bioavailable when the body creates it from punicalagin. Punicalagin has up to 10 times more antioxidant potency than ellagic acid, is 100% watersoluble, and has an absorption rate of 95%. It peaks in the bloodstream in just 60 minutes, moving through your whole system in 4-6 hours.

Standardized, potent and pure
Punicalagin is a type of polyphenol, a group of phytonutrients known for their antioxidant content. Pomegranate Plus contains a pomegranate extract derived from the whole fruit, standardized to no less than 30% punicalagin. Extracts, concentrates and juices that are not standardized can vary widely in their antioxidant content and run the risk of diminished antioxidant activity due to oxidation.
PUNICALAGIN MOLECULE
If you've already discovered the benefits of pomegranate and are looking for an unmatched antioxidant blend, Pomegranate Plus is for you. Every easy-to-take vegetarian capsule contains 300mg of pomegranate extract. Just 2 capsules have the total polyphenol (not just punicalagin) equivalent of 1 glass (250ml) of fresh pomegranate juice, and without the sugar, calories or additives. Pomegranate Plus is tested using state-of-the-art equipment and analyses, such as High Performance Liquid Chromatography (HPLC), guaranteeing purity, potency and quality. If you've never tried pomegranate . . . what are you waiting for?

What are free radicals and what causes them?
Free radicals do occur naturally, but in quantities too low to disrupt the body's state of balance. Chemicals, indigestible food additives and environmental pollutants introduce into our bodies elements that cannot be metabolized, producing an excess of free radicals that can create health concerns.

Free radicals are atoms that have lost a part and become unbalanced. They re-balance themselves by taking what they're missing from other atoms. This process is called "scavenging" and can be very dangerous. A free radical can scavenge from numerous atoms at once, turning each of them into a free radical. In this way free radicals multiply faster than the body can get rid of them. If there are too many free radicals in your body, scavenging can disrupt your entire system, leading to cell, tissue and organ damage, illness and even chronic conditions.

How Pomegranate Plus neutralizes free radicals
Antioxidants are special molecules that neutralize free radicals while maintaining their own structure, helping to return the body to a state of balance.

Different antioxidants focus on different areas of the body. Pomegranate Plus is a blend of 5 proven antioxidants, including punicalagin, that have been individually studied and shown to:
Improve circulation and support cardiovascular health (11)
Lower cholesterol (5,13)
Promote healthy eyesight (15)
Minimize chronic muscle pain and stiffness
Strengthen immunity (6)
Cross the blood-brain barrier
Slow the aging process (7)

ALL THE ANTIOXIDANTS IN POMEGRANATE PLUS HAVE BEEN CAREFULLY CHOSEN FOR THEIR PROVEN BENEFITS
Pomegranate fruit extract (Punica granatum), standardized to 30% punicalagin. An ancient food source recently discovered to demonstrate more antioxidant activity than red wine or ellagic acid
Contains the full spectrum of polyphenols found in pomegranates, including punicalagin, ellagitannins, gallotannins, anthocyanins and flavonoids such as quercetin
Slows down cholesterol oxidation, benefiting the heart and arteries (12)
Helps to promote healthy aging
Vitamin C (ascorbic acid)
An essential nutrient that helps boost the immune system (6)
Can assist in the normal development and maintenance of bones, cartilage, teeth and gums
A factor in the maintenance of good health
Can help enhance wound healing
Green tea leaf extract (Camellia sinensis), decaffeinated and standardized to 50% polyphenols
Contains antioxidants that help guard against cell damage
May aid in lowering cholesterol5
Can help diminish inflammation and pain caused by inflammation
May help to protect against sun damage (14) (NOT meant to take the place of sunscreen)
Grape seed extract (Vitis vinifera)
Clinically proven by 50 years of research, Masquelier's® Original OPCs (Oligomeric Proanthocyanidins) help reduce the visible signs of premature aging such as wrinkles and sagging skin (7)
Helps minimize chronic muscle pain and stiffness
Helps maintain healthy circulation
Small enough to cross the blood-brain barrier – an important consideration in protecting the brain against free radical damage
Bilberry fruit extract (Vaccinium myrtillus), standardized to 25% anthocyanidins
This antioxidant promotes improved blood flow to the eyes (15)
Can help to improve night time visual acuity and adjustment to light and dark (15)
May aid in the prevention of cataracts and macular degeneration (15)
Traditionally used to treat diarrhea and inflammation of the mucous membranes of the mouth and throat

FLORAdvantage:
5 of the most potent antioxidants (including punicalagin) for incomparable potency and antioxidant activity in one easy-to-take vegetarian capsule
A full-spectrum pomegranate extract made from handpicked, non-GMO pomegranates grown without pesticides or chemical fertilizers
2 capsules contain the total polyphenol equivalent of 1 glass (250ml) of fresh pomegranate juice without the sugar, calories or additives, and without the risk of oxidation
Tested using state-of-the-art equipment and analyses guaranteeing purity, potency and quality
Fast-acting, water-soluble ingredients
Non-toxic
Suitable for vegetarians

References:
(1) M.I. Gill et al., "Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing" (2000), 48 J Agric Food Chem: 4581-4589.

(2) B. Cerda et al., "Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice" (2003), 42 Euro J Nutr: 18-28.

(3) F. de Nigris et al., "Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells" (2006), 11 Nitric Oxide: Epub ahead of print.

(4) F. de Nigris et al., "Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress" (2005), 29 Proc Natrl Acad Sci USA: 4896-4901.

(5) M. Ali et al., "A potent thromboxane formation inhibitor in green tea leaves" (1990), 40 Prostaglandins Leukot Essent Fatty Acids: 281-283.

(6) E.S. Wintergerst et al., "Immune-enhancing role of vitamin C and zinc and effect on clinical conditions" (2006), 50 Ann Nutr Metab: 85-94.

(7) P. Sangeetha et al., "Age associated changes in erythrocyte membrane surface charge: Modulatory role of grape seed proanthocyanidins" (2005), 40 Exp Gerontol: 820-828.

(8) B. Doyle and L.A. Griffiths,"The metabolism of ellagic acid in the rat" (1980), 10 Xenobiotica: 247-256.
(9) R.C. Smart et al., "Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-O-decylellagic acid and 3,3'-di-O-methylellagic acid in mice" (1986), 7 Carcinogenesis: 1663-1667.

(10) F. Lei et al., "Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract" (2003), 796 J Chromatogr B Analyt Technol Biomed Life Sci: 189-194.

(11) M. Aviram and L. Dornfeld, "Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure" (2001), 158 Atherosclerosis: 195-198.

(12) B. Fuhrman, "Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages" (2005), 16 J Nutr Biochem: 570-576.

(13) M. Aviram et al., "Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans" (2002), 28 Drugs Exp Clin Res: 49-62.

(14) Z.Y. Wang et al., "Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7, 12- dimethylbenz[a]anthracene-initiated SKH-1 mice" (1994), 1 Cancer Res: 3428-3435.

(15) K. Head (Ed), " Vaccinium myrtillus(Bilberry)" (2001), 6 Alt Med Rev: 500-504.